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Large rectangular E-ATX motherboard, dark grey finish with silver heatsinks and multiple expansion slots

MSI

MSI MEG X399 CREATION AMD motherboard Socket TR4 DDR4 128GB E-ATX

SKU CH-2X68-9VZAY

Supports AMD RYZEN THREADRIPPER processors with four-channel DDR4 up to 128GB and 3600MHz OC, four PCIe 3.0 x16 slots, 7.1 audio, and dual Intel I211 LAN

  • CPU Socket TypeSocket TR4
  • CPU TypeAMD RYZEN ™ THREADRIPPER ™ processor with TR4 architecture
  • ChipsetAMD X399
  • Memory StandardSupport four-channel DDR4 3600 + (OC)/3466 (OC)/3333 (OC)/32
  • Maximum Memory Supported128GB
  • PCI Slots4 x PCIe 3.0 x16 slots 1 x PCIe 2.0 x1 slot
  • Supports 128GB quad-channel DDR4 up to 3600MHz overclocked
  • Four PCIe 3.0 x16 slots for multi-GPU or expansion cards
  • 10Gbps USB 3.1 Gen2 Type-C plus USB 3.1 Gen1 Type-A
  • Dual Intel I211 Gigabit LAN for reliable wired networking
  • Realtek ALC1220 7.1-channel audio with S/PDIF output

Socket TR4 for Threadripper workstations

This MSI MEG X399 CREATION motherboard accepts AMD RYZEN THREADRIPPER processors on Socket TR4. The AMD X399 chipset enables four-channel DDR4 memory up to 128GB with overclocked speeds reaching 3600MHz. Four PCIe 3.0 x16 slots and one PCIe 2.0 x1 slot provide extensive expansion for graphics, storage and compute cards. Dual Intel I211 Gigabit LAN and Realtek ALC1220 7.1 audio complete a platform aimed at content-creation and workstation builds.

E-ATX layout needs a compatible chassis

The board follows the E-ATX form factor so verify that your case supports this larger footprint before installation. Align the supplied I/O back panel, seat the CPU carefully in the TR4 socket and lock the retention mechanism evenly to avoid bent pins. Populate all four DDR4 slots for full quad-channel bandwidth. Connect the 8-pin and 4-pin EPS power headers; missing the secondary connector is a common oversight that prevents post. Route the front-panel headers using the included manual diagram.

Confirm cooler clearance and power delivery

Check that your CPU cooler mounting hardware lists TR4 compatibility and that its physical dimensions leave room for the VRM heatsinks. Ensure the power supply provides both EPS connectors required by the board. Verify that your memory kit appears on the MSI qualified-vendor list for the listed DDR4 frequencies. The package supplies the motherboard, a CMOS battery, one SATA cable and the I/O shield only; no additional brackets or Wi-Fi antenna are included.

Highlights

  • Supports 128GB quad-channel DDR4 up to 3600MHz overclocked
  • Four PCIe 3.0 x16 slots for multi-GPU or expansion cards
  • 10Gbps USB 3.1 Gen2 Type-C plus USB 3.1 Gen1 Type-A
  • Dual Intel I211 Gigabit LAN for reliable wired networking
  • Realtek ALC1220 7.1-channel audio with S/PDIF output

Specifications

BrandMSI
SeriesMSI MEG X399 CREATION
ModelMSI MEG X399 CREATION
CPU Socket TypeSocket TR4
CPU TypeAMD RYZEN ™ THREADRIPPER ™ processor with TR4 architecture
ChipsetAMD X399
Memory StandardSupport four-channel DDR4 3600 + (OC)/3466 (OC)/3333 (OC)/3200 (OC)/3066 (OC)/2933 (OC)/2800 (OC)/2667 (OC)/2400/2133MHz memory
Maximum Memory Supported128GB
PCI Slots4 x PCIe 3.0 x16 slots
1 x PCIe 2.0 x1 slot
SATA RAID3XM.2 interface, 8xSATA III interface
Audio ChipsetRealtek ALC1220 decoding chip
7.1 channel high-quality sound effects
Supports S/PDIF output
LAN Chipset2 Intel I211 Gigabit network interface cards
Onboard USBASMedia ASM3142 Chipset
1 USB 3.1 Gen2 (SuperSpeed USB 10Gbps) Type-C interface provided via onboard USB interface
AMD X399 chipset
1 USB 3.1 Gen1 (SuperSpeed USB) Type-A interface located on the backplane
1 USB 3.1 Gen1 (SuperSpeed USB) Type-C interface located on the backplane
4 USB 3.1 Gen1 (SuperSpeed USB) interfaces are provided via the onboard USB interface
Four USB 2.0 (High-speed USB) interfaces are provided through the onboard USB interface
AMD CPU
8 USB 3.1 Gen1 (SuperSpeed USB) Type-A ports on the back panel

Questions about this item

How do I verify the board is running DDR4 at 3600 (OC) after first boot?

Enter the firmware and confirm the memory frequency reads 3600 MHz; the Realtek ALC1220 audio and dual Intel I211 LAN ports will also appear in the hardware list.

What accessories are included and which cables must I provide?

The package contains the motherboard, a CMOS battery, one SATA cable and the rear I/O panel; any additional SATA cables, power leads or M.2 screws must be sourced separately.

Which memory capacity should I choose for four-channel DDR4 on this X399 board?

Populate all eight slots with identical DDR4 modules up to the 128 GB limit; matched kits at 3200 MHz or any supported OC speed will run in quad-channel mode.

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