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Rectangular ATX motherboard in dark grey with silver heatsinks and black PCIe slots

MSI

MSI X399 SLI PLUS AMD motherboard Socket TR4

SKU CH-3W54-M88FD

Socket TR4 board for AMD Ryzen Threadripper with four-channel DDR4 up to 3600 MHz, four PCIe 3.0 x16 slots, eight SATA ports, three M.2 interfaces, Intel I211 LAN.

  • CPU Socket TypeSocket TR4
  • CPU TypeAMD Ryzen Threadripper processor with TR4 architecture suppo
  • ChipsetAMD X399
  • Memory StandardSupport four-channel DDR4 DDR4 3600 + (OC)/3466 (OC)/3333 (O
  • Maximum Memory Supported128GB
  • PCI Slots4 PCIe 3.0 x16 slots 2 PCIe 2.0 x1 slots
  • Quad-channel DDR4 up to 3600 MHz for high memory bandwidth
  • 128 GB maximum capacity handles large workloads
  • Four PCIe 3.0 x16 slots enable multi-GPU configurations
  • Realtek ALC1220 delivers 7.1 channel audio
  • Intel I211 provides Gigabit LAN connectivity

Socket TR4 platform

The MSI X399 SLI PLUS motherboard pairs the AMD X399 chipset with a Socket TR4 interface for Ryzen Threadripper processors. Four-channel DDR4 support scales up to 128GB across a wide OC frequency range from 2133MHz to 3600MHz. Four PCIe 3.0 x16 slots and two PCIe 2.0 x1 slots give multi-GPU and add-in card flexibility for workstation builds.

Sustained workload behaviour

The X399 chipset and four-channel memory architecture keep bandwidth high during long render or compute sessions. Eight SATA III ports and three M.2 interfaces maintain storage throughput without throttling. Realtek ALC1220 audio and Intel I211 Gigabit LAN operate independently of the CPU, so background encoding or network transfers do not compete for processor resources.

Pre-order compatibility checks

Verify that your Threadripper CPU uses the TR4 socket and that your cooler mounting matches the platform. Confirm the power supply delivers the required EPS connectors for the board. Ensure the chassis can accommodate an ATX form factor and that rear I/O cut-outs align with USB 3.1 Gen2 Type-A, Type-C, S/PDIF and LAN ports.

Highlights

  • Quad-channel DDR4 up to 3600 MHz for high memory bandwidth
  • 128 GB maximum capacity handles large workloads
  • Four PCIe 3.0 x16 slots enable multi-GPU configurations
  • Realtek ALC1220 delivers 7.1 channel audio
  • Intel I211 provides Gigabit LAN connectivity

Specifications

BrandMSI
SeriesMSI X399 SLI PLUS
ModelMSI X399 SLI PLUS
CPU Socket TypeSocket TR4
CPU TypeAMD Ryzen Threadripper processor with TR4 architecture support
ChipsetAMD X399
Memory StandardSupport four-channel DDR4 DDR4 3600 + (OC)/3466 (OC)/3333 (OC)/3200 (OC)/3066 (OC)/2933 (OC)/2800 (OC)/2667 (OC)/2400/2133MHz memory
Maximum Memory Supported128GB
PCI Slots4 PCIe 3.0 x16 slots
2 PCIe 2.0 x1 slots
SATA RAID3XM.2 interface, 8xSATA III interface
Audio ChipsetRealtek ALC1220 decoding chip
- 7.1 channel high-quality sound effects
- Supports S/PDIF output
LAN Chipset1 Intel I211 Gigabit network interface card
Onboard USBASMedia ASM3142 Chipset
- 1 USB 3.1 Gen2 (SuperSpeed USB 10Gbps) Type-C interface located on the backplane
- 1 USB 3.1 Gen2 (SuperSpeed USB 10Gbps) Type-A interface located on the backplane
AMD X399 chipset
- 1 USB 3.1 Gen2 (SuperSpeed USB 10Gbps) Type-C interface provided via onboard USB interface
- 4 USB 3.1 Gen1 (SuperSpeed USB) ports are provided via the onboard USB port
- 6 USB 2.0 (High-speed USB) ports (2 ports on the backplane, 4 via onboard USB ports)
AMD CPU
- 8 USB 3.1 Gen1 (SuperSpeed USB) Type-A ports on the back panel

Questions about this item

How much power does the board itself draw when a Threadripper CPU is running all day?

The motherboard does not publish a standalone power-draw figure; total system consumption depends on the Threadripper model, memory kit and attached drives.

Which cooler mounting pattern and memory kit are required before this board will post?

You need a TR4-compatible cooler and a four-channel DDR4 kit up to 128 GB; the board accepts speeds from 2133 MHz to 3600 MHz (OC).

Will my older SATA SSDs and PCIe 2.0 expansion cards work in the available slots?

Eight SATA III ports support legacy SATA drives, and two PCIe 2.0 x1 slots accept older x1 cards; four PCIe 3.0 x16 slots handle newer GPUs.

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